- However, rats treated at the same dose for 6 weeks, or longer were infertile and showed severe degeneration of the seminiferous epithelium in the testes as well as marked decreases in testicular spermatid counts and epididymal sperm counts.
- Alcoholic beverages should be avoided while taking metronidazole and for at least three days afterward.
- If no therapeutic alternatives to metronidazole are available, and concomitant administration with busulfan is medically needed, frequent monitoring of busulfan plasma concentration should be performed and the busulfan dose should be adjusted accordingly.
- Oral metronidazole has been studied as a radiation sensitizer in the treatment of malignant tumors.
- Bioassay of metronidazole with either anaerobic or aerobic incubation.
- The reduced form of metronidazole and free radicals can interact with DNA leading to inhibition of DNA synthesis and DNA degradation leading to death of bacteria.
- Your dose will depend on your medical condition and your response to treatment.
- For patients with mild to moderate hepatic impairment, no dosage adjustment is needed.
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